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我们通常用 wget 或 curl 下载文件,然而由于NCBI和EBI网站都在国外,有时候下载速度非常慢,如果文件特别大,就可能非常难受甚至是不可能完全的任务了,这时可用aspera进行高速下载。


首先进入aspera官方网站,找到「IBM Aspera Connect」,进入下载页面,找到对应的版本与平台,这里以Linux平台最新的3.10.0版本为例进行介绍。


1. NCBI数据下载



先将要下载的文件的路径放入一个文件 file.lst 中,比如

-i 免密从NCBI或EBI下载的私钥,安装完成就有,位于 ~/.aspera/connect/etc/asperaweb_id_dsa.openssh
-l 最大下载速度,如100M
-k 断点续传,通常设为1
-T 无需加密传输
--host 服务器域名,NCBI为 http:// ftp.ncbi.nlm.nih.gov ,EBI下载千人基因组为 http:// fasp.1000genomes.ebi.ac.uk
-P 用于SSH认证的TCP商品,一般是33001
--user 用户名,NCBI为anonftp,EBI下载千人基因组为g1k
--mode 传输模式,上传为send,下载为recv